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Orlistat Uses
1. An antiobesity agent. A pancreatic lipase inhibitor. Antiobesity agent.
2. antidiabetic
3. Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.
4. Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption. Tetrahydrolipstatin is widely used for the treatment of obesity.
Orlistat Chemical Properties
| Melting point |
<50 °C |
| alpha |
D20 -32.0° (c = 1 in chloroform) |
| Boiling point |
615.9±30.0 °C(Predicted) |
| density |
0.976±0.06 g/cm3(Predicted) |
| storage temp. |
2-8°C |
| solubility |
DMSO: 19 mg/mL |
| form |
solid |
| pka |
14.59±0.23(Predicted) |
| color |
white |
| Merck |
14,6869 |
| InChIKey |
AHLBNYSZXLDEJQ-FWEHEUNISA-N |
| CAS DataBase Reference |
96829-58-2(CAS DataBase Reference) |
Orlistat powder (CAS NO.96829-58-2) is a drug designed to treat obesity. It is mainly used for preventing the absorption of fats from the human diet, thereby reducing caloric intake. Besides, it is intended for use in conjunction with a physician-supervised reduced-calorie diet.
| Item |
Requirements |
Test Results |
| Appearance |
while to off-while powder |
White powder |
| Identification |
HPLC retention time |
Conforms |
| Melting Point |
42 ºC -45°C |
42°C-44°C |
| Specific optical rotation |
-31.0°~-41.0° |
-36.0° |
| Purity by HPLC |
no less than 98.0% |
98.5% |
| Total impurity |
no more than 2.0% |
1.6% |
| Max Individual impurity |
no more than 0.5% |
0.3% |
| Water content%(K&F) |
no more than 0.5% |
0.1% |
| Residual solvents |
EtOH no more than 0.5% |
N.D |
| EtAC no more than 0.5% |
N.D |
| n-Heptane no more than 0.5% |
less than 0.1% |
| Residue on ignition |
less than 0.2% |
0.10% |
| Heavy metals as Pb |
no more than 20ppm |
less than20ppm |
| Assay (HPLC) |
no less than 98.0% |
99.60% |
| Conclusion |
Meets the Requirements |
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