Recently, Zhao Zongbao’s team, a researcher at the Dalian Institute of Chemical Physics, Chinese Academy of Sciences, has made new progress in the field of unnatural coenzyme research. They have developed nicotinamide cytosine dinucleotide (NCD) synthetase and NCD self-sufficient microbial cells, which have been successfully used to construct high Selective material metabolism pathway. Relevant research results were published in “Nature-Communication”. …

The main ways to synthesize NAD+ The synthesis of NAD+ is divided into salvage pathway, de novo synthesis pathway and Preiss-handler pathway according to different synthetic raw materials. a) De novo synthesis pathway: tryptophan (Trp) is converted to quinolinic acid (QA), and then converted to NAMN by quinolinic acid-phosphoribosyl transferase (QPRT). NAMN is converted into NAAD, and finally NAD+ is …